Urea in invert sugar tried in sickle cell crisis
A method for reversing a sickle cell crisis as well as blocking sickling of susceptible erythrocytes may have emerged from a theoretical investigation of the hemoglobin S molecule.
Experimental aspects of the technique were presented by a team of researchers during two recent meetings—the American College of Physicians and the Federation of American Societies for Experimental Biology. In an interview, Robert M. Nalbandian, MD, the group leader, described a single patient who experienced a sickle cell crisis and seemed to be successfully treated with intravenously administered urea in invert sugar.
The associate pathologist at Blodgett Memorial Hospital, Grand Rapids, Mich, said that a 20-year-old male African student attending a teachers' college in Kalamazoo, Mich, developed excruciating pain in the abdomen, bones, and chest. The patient was known to be homozygous for the hemoglobin S molecule.
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