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Lila Elveback, PhD
Mayo Clinic Rochester, Minn

JAMA. 1970;212(5):883.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Dr. Keating met his death in an automobile accident before our paper was published. I have consulted with his colleagues, Dr. Lynwood Smith and others (Sections of Internal Medicine), and Dr. Don Jones and Dr. John McCall (Section of Biochemistry). We would like to make the following points concerning Dr. Gambino's comments.

First, it is apparent from our paper that we were not estimating "maximum limits for the normal range" but rather the 2.5 and 97.5 percentage points of the distribution in healthy persons.

Next, Dr. Keating's colleagues support his statement concerning the clinical significance of the falsenegative values on serum calcium in the range from 10.1 to 10.3. As reported from here and elsewhere,^1-3 borderline hypercalcemia with symptomatic hyperparathyroidism occurs in a small but significant percentage of patients demonstrated to have the disease. Its recognition depends upon an accurately established normal range using the refined . . . [Full Text PDF of this Article]

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