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JAMA. 1970;212(9):1516.

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Goldblatt undertook his classic experiments¹ with an underlying premise. He was interested in the possibility that renal ischemia, due to intrarenal obliterative vascular disease, including nephrosclerosis, might be the cause rather than the result of "essential" hypertension. Since there was no way of producing such disease experimentally, constriction of the main renal artery by means of a clamp was employed, to simulate the effect of the naturally occurring intrarenal obliterative vascular disease. Persistent hypertension did, indeed, develop as a result of bilateral constriction of the main renal artery. Surprisingly, elevated blood pressure of varying duration also followed unilateral constriction. Further, in the dog with hypertension due to unilateral renal ischemia, removal of the ischemic kidney, or release of the clamp, was followed by prompt fall of the blood pressure to normal. The clinical implications of these findings were quickly grasped and applied, often rashly, with eclipse of the original . . . [Full Text PDF of this Article]

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