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Telfer B. Reynolds, MD; Allan G. Redeker, MD
Los Angeles

JAMA. 1970;213(13):2273.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In a recent letter (212:1961, 1970), Dr. Knut Naess questions whether "laxative jaundice" is in fact caused by oxyphenisatin as suggested by the previous articles in this journal (211:83-85, 86-90, 1970). He states that oxyphenisatin is "used much more in Europe than in the United States and as far as I know no complications have previously been described." He suggests that the combination with dioctyl sodium succinate may be necessary for toxicity.

It is, of course, redundant to point out that a reaction to a drug is nonexistent until it is noticed. Since publication of our article in this journal, we have seen four additional patients with liver disease that had a close temporal relationship with prolonged oxyphenisatin ingestion. One patient had rather severe histologic changes with collapse and fibrosis on the biopsy specimen. Another patient is of particular interest in relation to the point . . . [Full Text PDF of this Article]

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