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David A. Hendrickson, MD; W. Robert Anderson, MD
Minneapolis

JAMA. 1970;213(3):468.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor:—

Gynecomastia may complicate prolonged hormonal therapy for adenocarcinoma of the prostate. Formation of acinar tissue with secretory activity may also arise in the breast of a man, but examples have only rarely been cited. This unusual complication occurred in a patient developing marked breast enlargement concurrent with prolonged diethylstilbestrol (stilbestrol) therapy.

Report of a Case.—

A 62-year-old Negro was hospitalized at Hennepin County General Hospital in February 1969 for lumbosacral back pain attributed to metastatic prostatic carcinoma. Transurethral prostatectomy 13 years previously had revealed adenocarcinoma of the prostate. Following bilateral orchiectomy the patient received 5 mg of diethylstilbestrol daily continuously until December 1968 when bone survey confirmed osteoblastic lesions secondary to metastatic carcinoma throughout the vertebral column, clavicles, calvarium, and long bones of the extremities. Diethylstilbestrol administration was then increased to 15 mg three times daily for ten days and then tapered to 5 mg three times . . . [Full Text PDF of this Article]

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