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Charles C. Henriques, MD
Sacramento, Calif

JAMA. 1970;214(13):2336.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

With the growing awareness of hypersensitivity and various other undesirable side effects from aspirin and other salicylates, there has been increasing utilization of acetaminophen as a simple analgesic and antipyretic agent. Other available substitutes, such as phenacetin and the pyralozones, are used less often because of the frequency and severity of untoward reactions.

Acetaminophen in usual dosage may cause drowsiness, methemoglobinemia, and impaired mentation. Overdosage may cause chills, emesis, convulsions, and death from respiratory failure. There have been no published reports of hypersensitivity reactions to acetaminophen, but one manufacturer has nine such reported cases on file. Six of these cases developed pruritic maculopapular rash, one exhibited laryngeal edema and urticaria, and two others developed angioedema and anaphylactoid reactions. All reactions were said to be controlled by "symptomatic medication and withdrawal of the drug." The following case of an apparent fixed drug eruption due to acetaminophen is presented. . . . [Full Text PDF of this Article]

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