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M. L. Clark, MD; E. A. Serafetinides, MD, PhD; J. B. Wise, MD; J. P. Colmore, MD
Norman, Okla

JAMA. 1970;214(13):2339.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In a recent study involving antipsychotic drugs of various chemical structures, the apparent development of "drug-induced pigment deposits on the anterior lens" was noted in several subjects under all treatment conditions including placebo. Contrary to what is known concerning such pigment deposition under long-term, high-dose chlorpromazine hydrochloride therapy,¹ this occurred relatively rapidly (three months) on modest doses of various medications including a thioxanthine and a butyrophenone. Although we were alerted to the possibility of false-positives by the occurrence of these findings in the placebo group it was, nevertheless, some time before a proper explanation came to light. This occurred when DeLong's reference² to "axial punctuate opacities" came to the attention of the ophthalmologist carrying out the slit-lamp examinations in the study.

DeLong called attention to a benign condition in which small, punctate opacities occurred on the anterior lens capsules, often scattered sparsely into the anterior . . . [Full Text PDF of this Article]

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