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JAMA. 1970;214(4):675-686.

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Studies show nickel could play major metabolic role

Serum nickel elevation in patients after myocardial infarction—as well as the discovery of a nickel-containing protein in rabbit serum—suggest a metabolic role for nickel, but the mechanism remains unclear

The evidence that nickel may have an important role in mammalian physiology is becoming stronger and stronger.

Recent developments include:

• Isolation of a nickel-containing protein in rabbit serum by investigators at the University of Connecticut School of Medicine.
  
• Studies by this same group, headed by F. William Sunderman, Jr., MD, that showed substantial elevations of serum nickel in a high percentage of victims of acute myocardial infarction.
  
• Similar studies, as yet unpublished, by British investigators at The London Clinic, who found elevated serum nickel in 24 consecutive myocardial infarction patients.
  
• Further work by F. H. Nielson, PhD, an agriculture department chemist, who has produced symptoms of nickel deficiency
  

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