
Smallpox Vaccination for Chronic Herpetic Ulcers
Harvey J. Cohen, MD;
Wilfred Minkin, MD
JAMA. 1970;214(4):762.
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To the Editor.—
Neff and Lane state that smallpox vaccination as a treatment for herpes simplex may result in dire consequences. Of the nine cases cited, however, all had underlying diseases of the reticuloendothelial system or were receiving immunosuppressive therapy. Smallpox vaccinations as a treatment for herpes simplex in a patient without immunologic malfunction would not be expected to cause such complications. Immunologically impoverished patients suffer these sorts of complications from smallpox vaccination regardless of the reason for performing the procedure. This aspect should be emphasized. We do agree that smallpox vaccination has not been established as effective therapy for herpes simplex.
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