This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

JAMA. 1970;214(7):1280.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To Earl W. Sutherland, MD, who, in a series of brilliantly designed and carefully controlled experiments, discovered a new chemical intermediary, cyclic adenylic acid (AMP), and showed that it participates in a wide range of biochemical and physiological control and regulatory mechanisms.

By providing a comprehension of the role of cyclic AMP in regulating hormonal action at the cellular level, Dr. Sutherland has constructed a conceptual basis for understanding endocrine physiology in health and disease—a monumental contribution.

Dr. Sutherland demonstrated that cyclic AMP mediates a considerable variety of hormone actions. Subsequent work of many other scientists, all over the world, has contributed to the structure now arising on the foundation of Dr. Sutherland's discoveries. Thus, cyclic AMP is now known to be an intracellular agent, a key regulatory substance, and a master molecule of metabolic control and regulation, which is even involved in the control of the expression of genetic . . . [Full Text PDF of this Article]

Footnotes
The awards were presented to the recipients on Nov 12, 1970, at the New York University Medical Center, New York.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?