This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Robert A. Good, MD, PhD

JAMA. 1970;214(7):1289-1300.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Rapidly developing understanding of the lymphoid system and immunologic function make these exciting days in immunobiology. When I began my studies of the relation of structure to function in the lymphoid system nearly 27 years ago, the function of lymphocytes was enigmatic; we could see the role of plasma cells in antibody production only as through a distant haze. Understanding of the function of whole organs, including the thymus and spleen, was almost entirely lacking. The meaning of the beautiful anatomic organization of the lymphoid cells within the peripheral lymphoid organs, eg, lymph nodes, was completely unknown. Small, medium, and large lymphocytes were noted in the peripheral blood, but little was known about from whence they came, where they went, or what they did. It had already been proposed that lymphocytes carried or produced antibodies.¹ Some thought that they exhibited a sort of suicidal dissolution under the influence of . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pediatrics and Pathology, University of Minnesota, Minneapolis.

Footnotes
Presented as a 1970 Albert Lasker Clinical Medical Research Award Lecture, New York, Nov 12,1970.

Reprint requests to Box 494, University of Minnesota Hospitals, Minneapolis 55455 (Dr. Good).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?