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Herbert Meltzer, MD

JAMA. 1971;216(11):1856-1857.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Adenosine 3',5'-monophosphate (cyclic AMP) is currently of intense interest to scientists in many fields of biology and medicine. Cyclic AMP plays a central role in the mediation of hormonal actions and the regulation of metabolic processes.¹ There is considerable experimental evidence for an important role of cyclic AMP in brain function.² Intracellular cyclic AMP levels may be increased or decreased by a variety of hormones and neurotransmitters, probably through stimulation or inhibition of the activity of adenyl cyclase, the enzyme which synthesizes cyclic AMP.^1,2 The mode of action of theophylline and aminophylline in the treatment of heart failure and bronchial asthma has been attributed to the inhibition of phosphodiesterase (the enzyme which catabolizes cyclic AMP), producing increased intracellular cyclic AMP levels in the myocardium and bronchial muscle, which results in more vigorous myocardial contraction and in bronchial dilatation.³

Studies of hormonal and neutrotransmitter excesses, deficiencies, and . . . [Full Text PDF of this Article]

Author Affiliations
Pritzker School of Medicine University of Chicago

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