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J. Garrott Allen, MD
Stanford, Calif

JAMA. 1971;218(3):444-445.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. —

Barker and Murray¹ have recently claimed that patients with serum hepatitis whose incubation periods were protracted were less likely to be severely ill than those whose incubation periods were relatively short. The serum samples upon which these conclusions were based were derived from experimental subjects who had received minute quantities of icterogenic serum between 1951 and 1954—minute when compared with the usual amount of blood administered as a transfusion.^1-3

A review of previous reports in 1970 indicated that when serum samples are altered by lyophilization, irradiation, or storage at 20 C, the mean incubation time for icterogenic plasma is lengthened.⁴ Murray et al⁵ found that samples of a special pool of plasma they had prepared, which normally had an attack rate of 52%, was reduced to an attack rate of 5% (or one among 20 subjects) when incubated for six months at . . . [Full Text PDF of this Article]

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