This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Edward D. Freis, MD

JAMA. 1971;218(7):1009-1015.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It was by chance that I became involved in 1946 in the clinical evaluation of antihypertensive agents. After World War II, I had returned to Boston to complete my residency training in internal medicine and to work in hemodynamics research with Robert Wilkins at the Massachusetts Memorial Hospital. Surgical sympathectomy was then the popular method for treating hypertension and Dr. Wilkins was involved with Reginald Smithwick in assessing the cardiovascular and circulatory changes associated with this operative procedure. However, Dr. Wilkins and Chester Keefer had been asked by James Shannon, who was then director of the Squibb Institute for Medical Research, to work with the Institute in exploring the possibility of developing a successful chemotherapy for hypertension. The clinical evaluation of any drugs that might emerge in this project was assigned to me working under the direction of Dr. Wilkins.

The first drug tested was an outgrowth of the World . . . [Full Text PDF of this Article]

Author Affiliations
From the Veterans Administration Hospital, Washington, DC.

Footnotes
Presented as a 1971 Albert Lasker Clinical Research Award, New York, Nov 11, 1971.

Reprint requests to 866 United Nations Plaza, New York 10017 (Mrs. Fordyce).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?