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JAMA. 1972;221(1):66-67.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A half dozen antigens believed to be "specific" for malignant neoplasms have been reported.¹ Although all are detectable by immunochemical methods, only one, the alphafetoglobulin test for hepatoma, is "routinely" available. Nevertheless, much interest has been directed toward carcinoembryonic antigen (CEA), a glycoprotein found in cancer of the colon and in fetal colonic tissue.

As noted by Reynoso et al,² CEA was originally believed to be specific for entodermal carcinomas, especially carcinoma of the colon. However, the Roswell Park scientists, using a somewhat different method of assay, detected abnormal plasma levels of CEA in the nanogram range in 90 of 281 patients having nonentodermally derived malignant neoplasms. Included in the group were seven children with neuroblastoma, six with active disease having elevated CEA values, and one with inactive disease in whom the CEA value was within normal limits.

Whether or not the results shown by Reynoso et al . . . [Full Text PDF of this Article]

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