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John D. Catravas; I. W. Waters, PhD; W. Marvin Davis, PhD; J. P. Hickenbottom, PHD
School of Pharmacy University of Mississippi University

JAMA. 1975;231(13):1340-1341.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The accidental or suicidal consumption of large doses of amphetamine has been the cause of a number of fatalities in the past,¹ and it seems likely to continue because of the increasing abuse of this class of compounds. Several investigations have associated the stimulatory actions of amphetamine with an increased dopaminergic activity.^2,3 Therefore, we decided to test the effectiveness of haloperidol, a butyrophenone with a known antidopaminergic activity,⁴ as a possible antidote. A previous study in this laboratory showed haloperidol to be effective in antagonizing dextroamphetamine intoxication in rats.⁵

The experiments were performed on unanesthetized mongrel dogs. A lethal dose (LD₁₀₀) of dextroamphetamine sulfate (10 mg/kg) administered intravenously produced severe systemic and left ventricular hypertension, marked fluctuations in the central venous pressure, increases in cardiac output and heart rate, pronounced hyperthermia, elevations of the serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, . . . [Full Text PDF of this Article]

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