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Chronic Granulomatous Disease 1974
Robert J. Schlegel, MD
JAMA. 1975;231(6):615-617.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE office diagnosis of many newly discovered diseases caused by neutrophil dysfunction is now possible with the use of clinical criteria and relatively simple laboratory tests. Through techniques evolved in the course of elucidating rare inborn disorders, it is now feasible to approach commonplace impairments of neutrophil function which occur as secondary consequences of other diseases or of chemotherapy.
The advances were initiated, in part, by the recognition of a clinical entity, chronic granulomatous disease (CGD). Although a condition featuring hypergammaglobulinemia and chronic infection had been recognized by Janeway in Boston, and the inflammatory hallmark defined histopathologically as suppurative granulomata by Landing and Shirkey1 in Los Angeles, it was the intuitive perception of Good and his colleagues, Bridges and Berendes,2 and, later, Quie et al,3 which resulted in the definition: an inherited condition in which the neutrophils could engulf, but not kill, infectious microorganisms.
Subsequently, Quie and
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Pediatrics, Charles R. Drew Postgraduate Medical School (UCLA), and the Los Angeles County Martin Luther King Jr. General Hospital, Los Angeles. Dr. Schlegel is now at the National Academy of Sciences, Washington, DC.
Footnotes
Reprint requests to Institute of Medicine, WG-616G, National Academy of Sciences, 2101 Constitution Ave, Washington, DC 20418 (Dr. Schlegel).
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