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Lidocaine: Prophylactic Value in Myocardial Infarction
Hugh H. Hussey, MD
JAMA. 1975;231(6):627.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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In the early phase of acute myocardial infarction, death usually results from cardiogenic shock or ventricular fibrillation. Although the latter accounts for many sudden deaths that preclude medical attention, it is nevertheless true that ventricular fibrillation may occur at any time, especially during the early hours and days of the episode, and that it often can be converted to normal rhythm by administration intravenously of lidocaine hydrochloride.
The Dec 19, 1974, issue of The New England Journal of Medicine published back-to-back articles by Lie et al (291:1324-1326, 1974) and Valentine et al (291:1327-1331, 1974) on the value of early prophylactic administration of lidocaine in salvaging patients having acute myocardial infarction.
Lie and his co-workers conducted a double-blind, randomized study of 212 consecutive patients under 70 years of age admitted to the hospital within six hours of onset of symptoms of myocardial infarction. The results of the study are succinctly told
. . . [Full Text PDF of this Article]
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