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Frederic A. dePeyster, MD

JAMA. 1975;231(6):643-645.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ANATOMIC distribution^1,2 of large-bowel cancer is shown in the Figure. About 2% to 4% of the tumors arise from the anus. Grossly, cancer may be exophytic, ie, growing from the bowel wall into the lumen to produce a fungating mass, or an annular tumor threatening obstruction. Endophytic lesions occur as variably sized, "punched out" ulcers or extend intramurally without ulceration (linitis plastica). Table 1 lists the histopathologic features of bowel cancer, 95% of which are adenocarcinoma.³ Cloacogenic, transitional cell, and Paget extramammary and Bowen anogenital diseases are rare.

The neoplastic cell is generated in the lower two thirds of the cryptal column of colonic mucosa, where kinetic activity of normal mucous, columnar, and argentaffin cells occur. This activity is characterized by rapid proliferation and orderly migration to the surface, terminating by extrusion of the cell into the bowel lumen. Whereas the DNA synthesis decreases in the normal . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Surgery, Rush-Presbyterian—St. Luke's Medical Center, Chicago.

Footnotes
Reprint requests to Suite 514, 1725 W Harrison St, Chicago, IL 60612 (Dr. dePeyster).

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