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George Margolis, MD
Dartmouth Medical School Hanover, NH

JAMA. 1975;231(8):811.

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To the Editor.—

Although I am a neuropathologist, I am puzzled by the use of Laplace's law in the theoretical explanation of pressure neuropathy (229:1864, 1974). This is obviously because my frame of reference related to the application of this law in vascular disease,^1,2 ie, T=PxR where T is wall tension, P is distending pressure, and R is the radius. Here the effect of increased luminal pressure, multiplied by the vascular radius, on wall stress is self-evident. But in the case of externally applied pressure, would not such a directional force decrease rather than increase wall tension? . . . [Full Text PDF of this Article]

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