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Criteria for Classification of Systemic Lupus Erythematosus
Nathan B. Rabhan, MD;
Wilfred Minkin, MD
JAMA. 1975;231(8):846.
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In 1971, the American Rheumatism Association (ARA) Committee on Therapeutic Criteria proposed "Preliminary Criteria for the Classification of Systemic Lupus Erythematosus [SLE]".1Any four of the 14 items listed below, when present, indicate SLE.1
- Facial erythema (butterfly rash)
- Discoid lupus erythematosus
- Raynaud phenomenon
- Alopecia
- Photosensitivity
- Oral or nasopharyngeal ulceration
- Arthritis without deformity
- Lupus erythematosus cells
- Chronic false-positive serologic test for syphilis
- Profuse proteinuria
- Cellular casts
- Pleuritis or pericarditis
- Psychosis or convulsions
- Hemolytic anemia or leukopenia or thrombocytopenia
These criteria were formulated by computer analysis of 57 symptoms, signs, and laboratory findings in 245 patients (with "unequivocal SLE") under the care of 52 different rheumatologists in the United States and Canada. Insufficient data at the time of evaluating these records prevented further analyses of such commonly used tests as antinuclear antibody, Coombs test, anti-DNA antibody, tissue biopsies, and direct immunofluorescence of skin biopsy specimen.
The first six criteria relate
. . . [Full Text PDF of this Article]
Author Affiliations
New York
Footnotes
Address editorial communications to the Editor, 535 N Dearborn St, Chicago 60610
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