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Zenonas Danilevicius, MD

JAMA. 1975;231(9):965-966.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recently, in an editorial on HL-A histocompatibility antigen and rheumatic diseases (231:283, 1975), we have indicated that HL-A27 or W27 antigens are good genetic markers of many rheumatic diseases, especially of ankylosing spondylitis. Now, new evidence has been presented indicating that HL-A antigens may be involved in genetic predisposition to other diseases.

Nerup et al¹ examined 146 diabetic patients and found that antigens HL-A8 and W15 were found significantly more frequently in diabetics than in a group of 1,967 controls. The HL-A8 and W15 antigens were found almost exclusively in insulin-dependent diabetics. They seemed to be genetic markers for insulin-dependent diabetes. The increase of HL-A8 antigen was found mainly in juvenile diabetics; the antigen W15 was increased both in this group and in the maturity-onset diabetics, however, mainly in the insulin-dependent patients. These findings support the concept that insulin-dependent and insulin-independent diabetes are two distinct disease entities.

Svejgaard et . . . [Full Text PDF of this Article]

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