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C. R. Franks, MB, BS
London

JAMA. 1975;232(1):19-20.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I was interested to read Dr. Ablin's recent letter "Diethylstilbestrol Exposure and Lymphocytic Impairment" (229:1863, 1974).

In our own studies,¹ implanted HeLa tumors in estrogen-treated female mice survived longer than those in untreated control mice. Furthermore, these mice experienced a profound lymphopenia. Although a less marked lymphopenia also occurred in estrogen-treated male mice, HeLa tumors in such mice regressed before those in control mice did.

Androgen treatment of female mice, on the other hand, resulted in a rapid lymphocytosis, and there was regression of HeLa tumors before similar tumors regressed in control mice. In male mice, androgen produced a marked and lasting lymphopenia. HeLa tumors in such mice survived beyond those in controls.

In all these studies, a non-hormonedependent tumor was used, and yet it was possible to influence the growth of tumors. The evidence would appear to suggest there has been a change in cell-mediated . . . [Full Text PDF of this Article]

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