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Piero P. Foà
Chairman Department of Research Sinai Hospital of Detroit

JAMA. 1975;232(1):21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I read the very interesting article entitled "Successful Medical Adrenalectomy with Aminoglutethimide" by Santen et al (230: 1661, 1974), and I was surprised by their statement that the use of the drug in the treatment of breast carcinoma was suggested for the first time by Griffiths et al in 1973.

In fact, a detailed description of the steroidogenic-blocking effect of amino-glutethimide was published by Cash and his collaborators in 1967.¹ That article described the mechanism of action of the drug and its utilization in the treatment of breast carcinoma, with complete relief of bone pain and histologic proof of the drug's effect on the adrenal glands of the patient. The same article also suggests the use of "potent pituitary-inhibiting synthetic steroids" to block the compensatory increase in secretion of adrenocorticotropic hormone, thus preventing amino-glutethimide "escape." . . . [Full Text PDF of this Article]

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