 |
|
Agranulocytosis Associated With Gentamicin
Jae C. Chang, MD;
Bienvenido Reyes, MD
JAMA. 1975;232(11):1154-1155.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
GENTAMICIN is an aminoglycoside antibiotic derived from Micromonospora purpurea. It has broadspectrum antibacterial action against most strains of Staphylococcus, Escherichia, Enterobacter, and Pseudomonas,1 and has been widely used in clinical practice with satisfactory results. However, like many other antibiotics, it is not without side-effects. The more frequently reported adverse reactions are nephrotoxicity, neurotoxicity, and allergic skin reactions.2
No serious hematologic complications have been recorded although transient granulocytopenia has been observed.3,4 We recently encountered a patient who had agranulocytosis associated with gentamicin and who recovered without any serious incident.
Report of a Case
A 68-year-old man was admitted to the Veterans Administration Hospital, Dayton, on May 6, 1974, with chief complaints of shortness of breath and chronic cough from an acute exacerbation of chronic obstructive lung disease. On admission, the patient was emaciated, appeared chronically ill, and was in moderate respiratory distress. Vital signs included a temperature of
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Medicine (Hematology), Veterans Administration Center, Dayton, and Ohio State University College of Medicine, Columbus, Ohio.
Footnotes
Reprint requests to Veterans Administration Center, 4100 W Third St, Dayton, OH 45428 (Dr. Chang).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
