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Leonard B. Berman, MD

JAMA. 1975;232(11):1161.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The Pharmacological Basis of Therapeutics, by L. S. Goodman and A. Gilman (New York, Macmillan Co, 1970), is the familiar and comforting title of this grand old text. But we live in an age in which the absence of kidney function is compatible with life. We need, therefore, an equally familiar supplementary volume dealing with pharmacology in anephric or nearly so patients. At least we can ask the right questions about the behavior of a medicinal agent in a uremic patient:

1. Is absorption of the agent from the gastrointestinal tract normal?
   
2. Is the renal clearance of active agent a significant fraction of the total clearance? (Significance, in this beholder's eye, is 30% or greater.)
   
3. Is a higher than normal blood level of the active drug toxic?
   
4. Is a higher than normal blood level of inactive metabolites toxic?
   
5. Is the drug dialyzable?
   
6. Does the uremic
   

Author Affiliations
Editorial Board, JAMA

Footnotes
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