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Fred E. Pittman, MD, PhD; Joan C. Pittman, MA; Charles D. Humphrey, PhD
Medical University of South Carolina Charleston

JAMA. 1975;233(13):1355.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

It should be noted in the report by Burbige and Milligan (231:1157, 1975) on the apparent successful use of the anion-exchange resin, cholestyramine, in two cases of colitis associated with lincomycin and clindamycin, that one of the patients was constipated for four days postoperatively and that both were given constipating agents when diarrhea began. One received paregoric, codeine, and an atropine sulfate-diphenoxylate hydrochloride mixture (Lomotil), the other Lomotil alone. In our early experience with colitis following lincomycin administration,¹ we noted that those patients with the most severe mucosal injury, as well as those with prolonged symptoms and sigmoidoscopic findings, gave histories of chronic constipation or had been given Lomotil at the onset of diarrhea. The bacteriologic and light and electron microscopic studies of mucosal biopsy specimens did not suggest bacterial overgrowth or invasion. These clinical observations, coupled with the knowledge that lincomycin is very poorly absorbed . . . [Full Text PDF of this Article]

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