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Jordan L. Holtzman, MD, PhD; Rex B. Shafer, MD

JAMA. 1975;233(7):817.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In recent years, the radioimmunoassay for digoxin has gained widespread acceptance for identifying digoxin intoxication in patients. It is of particular value in those patients who have manifestations of arteriosclerotic cardiovascular disease as arrhythmias, which are also the signs of digitalis intoxication. Even in the initial studies on the clinical application of this assay, there was a substantial overlap in the digoxin levels observed for the intoxicated and nonintoxicated patients.¹ Several workers have suggested that some of this overlap could be a result of the assay itself not giving the true value for the serum concentration.^2—4 In a recent study, we have found that there is indeed a group of patients for whom the determination of serum digoxin concentrations will give an erroneously low value.⁵

In the routine clinical application of the radioimmunoassay, the fraction of labeled drug bound to antibody is compared to a calibration curve . . . [Full Text PDF of this Article]

Author Affiliations
Minneapolis

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