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Observations, Controversy, and Lessons

Nicholas J. Vianna, MD, MSPH

JAMA. 1975;234(11):1133-1134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN CONTRAST to the other lymphomas, which have always been regarded as neoplastic disorders, there has been incessant controversy over the nature of Hodgkin disease. Is it infectious, neoplastic, inflammatory—none, all, or some of these? We should be quick to recall that Wilks, Mallory, Warthin, Sternberg, and Reed pondered over these very same considerations, as have a countless number of other students of this disorder, which was first described in 1832. More recently, it has been hypothesized that Hodgkin disease in the young might be infectious in nature, whereas in the elderly it behaves like a neoplasm.¹ Another series of epidemiologic studies² suggests that in certain settings, most notably schools, this disease might have an infectious component.

Despite all the efforts over the past century, the fact remains that we have failed to elucidate the nature of Hodgkin disease. The reason or reasons for this may well be . . . [Full Text PDF of this Article]

Author Affiliations
Albany, NY

From the State of New York Department of Health, Albany.

Footnotes
Reprint requests to Tower Building, Empire State Plaza, Albany, NY 12237 (Dr Vianna).

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