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JAMA. 1975;234(2):204-205.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Therapeutic-Drug Malabsorption Not Observed After Jejunoileal Bypass

Q A patient who had a jejunoileal bypass operation has not responded to treatment of otitis media with cephalexin monohydrate (Keflex), 500 mg four times a day (she is allergic to penicillin). An otolaryngologist cannot account for the failure of response to the antibiotic. Are there reports of therapeutic-drug malabsorption in patients after they have had a jejunoileal bypass operation?

D. R. WEBB, MD Beaumont, Texas

A I know of no published data on the absorption of orally administered antibiotics after a jejunoileal bypass operation. We are currently embarking on a cooperative study of postoperative drug absorption; however, we are starting with the digitalis preparations. I would suggest that you administer to your patient cephalothin sodium (Keflin) intramuscularly. If the patient does not respond, then you and the otolaryngologist must seek an explanation for a failure of response elsewhere than in an absorptive . . . [Full Text PDF of this Article]

Footnotes
Edited by George X. Trimble, MD, Contributing Editor.

The answers here published have been prepared by competent authorities. They do not, however, represent the opinions of any medical or other organization unless specifically so stated in the reply. Anonymous communications cannot be answered. Every letter must contain the writer's name and address, but these will be omitted on request. All inquiries receive a direct mail reply.

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