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Joseph E. Herman, MD; Harry M. Bassan, MD

JAMA. 1975;234(3):310-311.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SALIENT features of quinidine-induced liver injury that have come to light from earlier reports are fever; a mixed typeof hepatic injury; a rapid return of the enzyme tests to normal on withdrawal of quinidine; and a shortening of the latency period on reexposure to the drug, with fever and disordered liver function appearing sooner and after progressively smaller doses.^1-3 The features are similar to those caused by other hepatotoxic agents leading to a hypersensitivity type of liver injury.^4-5 We are describing a patient whose clinical course after quinidine ingestion showed all of the above features and who, in addition, evidenced prolonged hepatocellular damage on testing with sulfobromophthalein sodium (Bromsulphalein).

Report of a Case

A 65-year-old man, married and the father of two, was admitted to the Central Emek Hospital Afula, Israel, because of fever of two weeks' duration. Prior to the onset of his illness, the patient . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine "A," Central Emek Hospital, Afula, Israel.

Footnotes
Reprint requests to Department of Medicine "A," Central Emuk Hospital, Afula, Israel (Dr Bassan).

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