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Richard K. Root, MD
University of Pennsylvania School of Medicine Philadelphia

JAMA. 1975;234(4):381.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I read with interest the article by Dr Schlegel on "Chronic Granulomatous Disease 1974" (231:615, 1975). For the sake of setting the record straight, it is worthwhile to note that patients with the Chédiak-Higashi syndrome do not have a "predilection to infection secondary to deficient phagocytosis." Rather, they have combined defects in chemotaxis as noted in the article by Clark and Kimball¹ (Schlegel's reference 20) and intracellular killing of ingested bacteria due to deficient degranulation of their giant lysosomes² as well as neutropenia.³ Phagocytosis by Chédiak leukocytes is normal to increased.⁴

Also, the patient described in Schlegel's reference 23 as having increased susceptibility to infection on the basis of a serum inhibitor of chemotaxis has, by all the classical criteria stated by Dr Schlegel, sex-linked chronic granulomatous disease of childhood when studied extensively in my laboratory.^2,5 This is probably much more instrumental . . . [Full Text PDF of this Article]

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