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Ronald G. Strauss, MD
St Jude Children's Research Hospital Memphis

JAMA. 1975;234(4):381-382.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

An attempt was made in Dr Schlegel's article to update the current thinking about chronic granulomatous disease of childhood. It is likely that this syndrome is an expression of several disease entities, and until the precise molecular defect(s) is identified, it is prudent to discuss the disorder in general terms. It was, of course, impossible for Dr Schlegel to include all available data in such a brief commentary; however, a few points were made that are at variance with the literature.

Cytoplasmic granules of neutrophils are discussed in the third paragraph. It appears that the term "lysosomes" is used to encompass all types of neutrophilic cytoplasmic granules. These structures have been divided by Bainton et al¹ into two broad groups and labeled as primary (azurophilic) and secondary (specific). Although both types are membrane-limited, it is somewhat imprecise to classify the latter as lysosomes since they do . . . [Full Text PDF of this Article]

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