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Richard S. Buswell, MD; Martin S. Lefkowitz

JAMA. 1976;235(11):1111.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT IS well documented that many patients with asthma have adverse reactions to aspirin.^1-4 A number of these same patients will have similar reactions to tartrazine (FD and C Yellow No. 5). The incidence of tartrazine sensitivity varies, depending on the study that is reported.

Samter and Beers¹ found that 14 of 182 aspirin-sensitive patients were also sensitive to tartrazine (< 8%). In another study,² they described 3 of 80 aspirin-sensitive patients who reacted to 25 mg of tartrazine. However, Juhlin et al⁵ found that seven of eight aspirin-sensitive patients reacted with asthma, urticaria, or both after 1 to 2 mg of tartrazine. A later article by Michaelsson and Juhlin⁶ reported that tartrazine provocation induced objective adverse reactions in 21 of 52 patients with a history of chronic urticaria or angioedema. Moreover, two of these patients had no apparent sensitivity to aspirin. They also noted . . . [Full Text PDF of this Article]

Author Affiliations
National Jewish Hospital and Research Center Denver

From the Division of Pediatric Clinical Immunology (Dr Buswell) and the Pharmacy Service (Mr Lefkowitz), National Jewish Hospital and Research Center, Denver.

Footnotes
Reprint requests to Division of Pediatric Clinical Immunology, National Jewish Hospital and Research Center, 3800 E Colfax Ave, Denver, CO 80206 (Dr Buswell).

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