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J. T. Lie, MD

JAMA. 1976;235(11):1148.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Whipple disease (intestinal lipodystrophy) is a systemic disorder that involves not only the small bowel and lymph nodes but also the liver, spleen, heart, brain, and other organs. Histopathologically, the disease is characterized by the ubiquitous macrophages that give a positive diastase-resistant PAS staining reaction. Although Whipple disease can be treated with antibiotics, its etiology remains one of the unsolved riddles of medicine, that is, perhaps, until now.

Clancy and associates¹ recently reported in the British Medical Journal that a cell wall-deficient form (CWD) of an -hemolytic Streptococcus was grown from a prolonged monolayer cell culture of a lymph node taken from a patient with Whipple disease. Serological cross reactivity was shown between the organisms and the material within Whipple disease macrophages. In vitro studies characterized the organisms as a facultative intracellular parasite that caused the accumulation within cells of PASpositive material. Moreover, parenteral injection of this CWD organism into . . . [Full Text PDF of this Article]

Author Affiliations
Baylor College of Medicine Houston

Footnotes
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