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Diuretic-Induced Interstitial NephritisOccurrence in a Patient With Membranous Glomerulonephritis
Thomas J. Fuller, MD;
Camilo G. Barcenas, MD;
Martin G. White, MD
JAMA. 1976;235(18):1998-1999.
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HYPERSENSITIVITY reactions in association with thiazide diuretics and furosemide include dermatitis, pneumonitis,1 vasculitis,2 allergic purpura with glomerulonephritis,3 and possible allergic interstitial nephritis causing reversible renal failure.4 We report a patient with long-standing membranous glomerulonephritis in whom rapidly progressive azotemia developed while he was taking a combination of furosemide and hydrochlorothiazide.
Report of a Case
A 60-year-old man was referred to the Dallas Veterans Administration Hospital on Dec 12, 1974, for dialysis because of progressive azotemia, weakness, and peripheral edema. In October 1958, he was hospitalized for generalized edema and albuminuria (4 + ). He received steroids orally over a period of one year and responded with a decrease in proteinuria and loss of edema. The patient remained asymptomatic except for occasional ankle edema and moderate albuminuria for 15 years. In November 1973, the patient was admitted with hypertension (160/105 mm Hg), pitting edema, and proteinuria (4+ ). His course
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Internal Medicine, Veterans Administration Hospital, Dallas, and the Department of Internal Medicine, University of Texas Southwestern Medical School.
Footnotes
Reprint requests to Baylor University Medical Center, 3500 Gaston Ave, Dallas, TX 75246 (Dr White).
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