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Alex C. Miller, Jr, MD; William M. Reid, MD

JAMA. 1976;235(18):2001-2002.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

METHYLDOPA has been an effective and usually well-tolerated antihypertensive agent in clinical practice. However, hypersensitivity reactions to the drug are well documented and have been manifested by fever, constitutional complaints, and liver disease.^1-7 We report a case of granulomatous hepatitis due to methyldopa therapy. To our knowledge, similar histopathologic changes have not been reported previously.

Report of a Case

A 49-year-old woman with previously well-documented essential hypertension was admitted to Carraway Methodist Medical Center in June 1973 with a five-day history of generalized repetitive chills, temperature of 39 to 40 C, myalgias, mild watery diarrhea, and severe nausea and vomiting. Her past medical history was unremarkable except for hypertension, which had been managed with hydrochlorothiazide for two years. Two days prior to the onset of her clinical illness, methyldopa, 250 mg twice daily, was added to her antihypertensive regimen.

On physical examination, she was alert, acutely ill, and dehydrated . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Internal Medicine, Norwood Clinic (Dr Miller), and the Department of Internal Medicine, Carraway Methodist Medical Center (Dr Reid), Birmingham, Ala.

Footnotes
Reprints not available.

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