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Occurrence Two Years Apart During Late Pregnancy in Two Sisters

Wolfgang E. Fuchs, MD; James N. George, MD; Laurence N. Dotin, MD; David A. Sears, MD

JAMA. 1976;235(19):2126-2127.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THROMBOTIC thrombocytopenic purpura (TTP) is an acute, usually fatal syndrome of unknown etiology, characterized by fever, thrombocytopenia, microangiopathic hemolytic anemia, and central nervous system and renal abnormalities. It is more common in women than men, and in 20 reported cases, the onset was during pregnancy.¹ Familial occurrences in siblings² and concomitant occurrence in a husband and wife³ have been reported. The hemolytic-uremic syndrome, which may be clinically identical to TTP, has also been reported to occur in families.^4-6

We report here the occurrence of the classical syndrome of fatal TTP in two sisters (Table). In each sister, the disease began suddenly, near the end of her first pregnancy: one in September 1972, the other in September 1974. eralized weakness in the 36th week of her first pregnancy. Four days later, she experienced transient numbness and paresthesias on the left side

Report of Cases

CASE 1.— . . . [Full Text PDF of this Article]

Author Affiliations
From the divisions of hematology (Drs Fuchs, George, and Sears), and renal disease (Dr Dotin), Department of Medicine, University of Texas Health Science Center at San Antonio.

Footnotes
Reprint requests to Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284 (Dr Sears).

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