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Zenonas Danilevicius, MD

JAMA. 1976;236(19):2213.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Crohn disease is most frequently confined to the small intestine with 90% of the cases involving the terminal ileum, but it also occurs in the colon and other parts of the intestinal tract. Its clinical course has similar and dissimilar features to that of ulcerative colitis. Hypotheses concerning etiology of Crohn disease have been very vague until now.

Crohn disease is often marked by anergy; however, the granulomatous nature of the disorder reminds one of an inflammatory reaction. It is obvious that ulcerative colitis and Crohn disease are two distinct and separable entities.

Mitchell and Rees¹ in 1970 and Cave et al² in 1973 showed that it is possible to transmit to experimental animals a condition similar to Crohn disease by filtrates of human ileum with Crohn disease. This led to suspicion that Crohn disease may be caused by a virus.

Recently more information began accumulating and tended . . . [Full Text PDF of this Article]

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