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Sergio V. Cabizuca, MD; Kenneth B. Desser, MD

JAMA. 1976;236(8):956-957.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1968, Brunner and Frick reported severe metabolic alkalosis and hypokalemia in patients receiving large doses of penicillin G sodium.¹ It was suggested that penicillin promoted urinary potassium excretion by acting as a nonreabsorbable anion. Subsequently, correspondence in the medical literature implicated carbenicillin as another possible cause of hypokalemic alkalosis.^2-4 We report here the development of hypokalemia, hypochloremia, and metabolic alkalemia during the course of intravenous administration of carbenicillin disodium in a patient with pulmonary Pseudomonas infection. Serial arterial blood gas studies clearly demonstrated metabolic alkalosis in this patient.

Report of a Case

A 61-year-old woman had a recent thoracotomy and biopsy of a mass that demonstrated squamous cell carcinoma of the right upper lobe with metastases to the pleura and regional lymph nodes. After a week's course of postoperative radiation therapy, there was an onset of fever and a productive cough. Two sputum cultures were positive for . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine (Dr Cabizuca) and Institute for Cardiovascular Diseases (Dr Desser), Good Samaritan Hospital, Phoenix, Ariz.

Footnotes
Reprint requests to Good Samaritan Hospital, 1033 E McDowell Rd, Phoenix, AZ 85006 (Dr Desser).

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