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2. Guidelines for Clinical Use

James L. Tullis, MD

JAMA. 1977;237(5):460-463.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PARTLY on the basis of the physiologic information given in part 1 and partly on the basis of empiric observations derived from uncontrolled clinical administration, it is believed pertinent to propose guidelines for the contemporary therapeutic use of albumin, an important plasma protein.

The guidelines for this biologic are designed to assure appropriate use. Certain principles were followed in preparation of the recommendations. (1) It was believed that the selection of proper clinical circumstances for the therapeutic use of albumin should not be dictated by arbitrary or pragmatic restrictions but rather by the education of physicians in its normal physiologic function. (2) Although only a few specific disorders regularly require the use of albumin, a broad diversity of pathologic complications may justify its occasional use. (3) Many clinical disorders exist in which there is incomplete or conflicting data on the effectiveness of albumin therapy. (4) Still other disorders exist in . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, New England Deaconess Hospital; the Department of Medicine, Harvard Medical School; and the Center for Blood Research, Boston.

Footnotes
This comprehensive review of the biochemistry, physiology, and clinical use and abuse of albumin is based on the Proceedings of the Workshop on Albumin sponsored by the Division of Blood and Blood Products, Bureau of Biologics; the Division of Blood Diseases and Resources, National Heart and Lung Institute; and the National Institutes of Health, Feb 12 through 14, 1975.

The author has had an exchange of views on this text with representatives of the Council of Europe Coordinated Blood Transfusion Research Programme (1976).

The 59 contributors whose work comprises the substance of this report are listed on page 462. The full text of each article is available in a bound volume published by the National Institutes of Health.

Reprint requests to Bldg 31, Room 4A-08, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20014 (Dr Anthony René).

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