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Themistocles Karpathios, MD; Polyxeni Nicolaidou, MD; Anastasios Korkas, MD; Theodore Thomaidis, MD

JAMA. 1977;238(14):1540-1541.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE HAND-FOOT syndrome is a well-documented manifestation of sickle cell anemia; whether it is equally common in sickle cell β-thalassemia (S/thal) disease seems unlikely, since published reports are scarce.^1,2

We report an infant with S/thal whose first clinical manifestations were pallor, fever, and painful, red swelling of both hands.

Procedures

An 11-month-old boy was admitted to the First Department of Pediatrics of Athens University. He had a high fever and edema of both hands of five days' duration, which did not regress during oral antibiotic therapy. A sister aged 6 years has S/thal disease. The family comes from Trikala of Thessaly, a region of Greece with a high frequency of sickle cell and β-thalassemia traits. Physical examination showed a pale, sick-looking infant. Temperature was 39 °C. Weight was 7,800 g, ie, below the third percentile, and height 77 cm, which corresponds to the 50th percentile. There was a spectacular . . . [Full Text PDF of this Article]

Author Affiliations
From the 1st Department of Pediatrics, Athens University at Aghia Sophia Children's Hospital, Athens 608, Greece.

Footnotes
Reprint requests to Department of Pediatrics, Athens University, Aghia Sophia Children's Hospital, Athens 608, Greece (Dr Thomaidis).

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