This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Irene Stachura, MD
Booth Memorial Medical Center Flushing, NY

JAMA. 1977;238(7):580-581.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Authors of the CLINICAL NOTE "Urinary Ultrastructural Findings in Fabry Disease" (237:1121, 1977), Sheila M. Katz, MD, and Patricia J. Lyons, MD, concluded that electron microscopic examination of the urine may be useful in the diagnosis of Fabry's disease with renal involvement.

In 1970 Duncan¹ reported three cases of Fabry's disease studied by electron microscopy. In two of his cases urinary sediment showed the presence of laminated, round osmiophilic bodies, similar to those found in renal foam cells. Duncan suggested that electron microscopic studies of urine for osmiophilic bodies may be of use as an indication of glomerular recovery in a follow-up of treated patients.

Recently electron microscopic studies of gingival mucosa have also been used in the diagnosis of Fabry's disease. Osmiophilic bodies were found in endothelial, perithelial, fibroblastic, phagocytic, and epithelial cells of gingival mucosa of affected persons.²

Early diagnosis of this interesting . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?