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Absence of an Association

Robert B. Wallace, MD; Barry M. Sherman, MD; Judy A. Bean, PhD; James Leeper, PhD

JAMA. 1978;239(10):958.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1976, Kapdi and Wolfe¹ reported that among women undergoing mammography, the prevalence of breast cancer was higher among those who had received thyroid hormone therapy than among those who did not. A reanalysis of the published data² showed that breast cancer frequency correlated with increasing age, and that within each group there was no clear-cut relationship with the presence or duration of thyroid hormone therapy. In a companion article, the American Thyroid Association³ reviewed the biological and statistical evidence for a role of thyroid hormone therapy in the cause and pathogenesis of breast cancer. They found the evidence for this relationship tenuous, and recommended that patients taking thyroid hormones for well-established indications continue to take their medications.

In a case-control study testing menstrual and reproductive hypotheses relating to breast cancer risk at the University of Iowa, we have collected information concerning the use and duration of . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Preventive Medicine and Environmental Health (Drs Wallace, Bean, and Leeper), and Internal Medicine (Dr Sherman), University of Iowa, Iowa City.

Footnotes
Reprint requests to Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City, IA 52242 (Dr Wallace).

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