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Lloyd J. Lemmen, MD; Marilyn Klassen, RN; Barbara Duiser, RN

JAMA. 1978;239(19):2025.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

LIDOCAINE, combined with other anticonvulsant medications, often dramatically halts repetitive convulsions. The addition of lidocaine to the anticonvulsant medication program may afford control of seizures without heavy sedation. While high blood levels of local anesthetic can themselves induce convulsions, there is a lower dosage range wherein lidocaine exerts pronounced antiepileptogenic effects in man and animal.

Experimental and clinical studies indicate that in higher dosages, lidocaine activates limbic structures, eg, hippocampus and amygdala.¹ Single doses of lidocaine, 2 to 3 mg/kg or 6 to 10 mg/kg/hr, have been suggested along with a barbiturate given at 3 mg/hr, for the control of status epilepticus in man.²

The Table lists the four patients, with ages ranging from 15 to 61 years and with weights ranging from 52 to 70 kg, we treated by various modes of administration of intravenous (IV) lidocaine. Complete seizure control was attained in each instance.

Complications

Lidocaine . . . [Full Text PDF of this Article]

Author Affiliations
From the Section of Neurosurgery and Neurology, Hackley Hospital, Muskegon, Mich.

Footnotes
Presented at the Continuing Medical Education Meeting, Hackley Hospital, Muskegon, Mich, July 25, 1977.

Reprint requests to 1724 Peck St, Muskegon, MI 49441 (Dr Lemmen).

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