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Richard J. Bonforte, MD
The Mount Sinai Medical Center New York

JAMA. 1978;240(17):1855.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

All of us who care for patients with cystic fibrosis (CF) are well aware of the varying degrees of clinical involvement they have. Indeed, over the past several years our concept of this disease has broadened considerably. No longer do we think of it solely as a pulmonary or a gastrointestinal illness. In actuality it is a systemic disease characterized by exocrine gland dysfunction. The recent article by Stern et al, "Intermediate-Range Sweat Chloride Concentration and Pseudomonas Bronchitis" (239:2676, 1978), presents well-documented clinical material that strongly suggests a genetic basis for what might be called a variant of CF.

The authors' patients all have pulmonary lesions classically associated with CF but without any pancreatic lesions. More important, sweat chloride concentrations were intermediate between the "normal" and "typical CF" range. It has long been known that whereas most patients have pulmonary involvement of one degree or another, approximately . . . [Full Text PDF of this Article]

Footnotes
Edited by John D. Archer, MD, Senior Editor.

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