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Alfred Doscherholmen, MD
Veterans Administration Hospital Minneapolis

JAMA. 1978;240(19):2045.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Radiocyanocobalamin (⁵⁷Co-B₁₂), mixed separately in vitro with ovalbumin and egg yolks, cooked and served to normal volunteers, was poorly absorbed as compared with a dose of crystalline⁵⁷Co-B₁₂.¹ This finding led to the conclusion that ovalbumin and egg yolk inhibit the gastroin testinal assimilation of vitamin B12. The validity of this conclusion may be open to question, since it was based on a comparison between the absorption of cooked radioactive vitamin B12 in the eggs and noncooked crystalline radiocyanocobalamin.

The present study eliminated this inconsistency of design by comparing the gastrointestinal absorption of noncooked radioactive vitamin B12 administered in a watery solution with that of a similar dose incorporated into raw egg yolks and ovalbumin (Table). Crystalline⁵⁷Co-B₁₂ mixed with the raw yolks of two eggs was ingested by a normal volunteer. The test was repeated two weeks later with . . . [Full Text PDF of this Article]

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