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Quentin R. Regestein, MD
Peter Bent Brigham Hospital Boston

JAMA. 1979;242(23):2558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Although there may be no specific association between menopause and depressive symptoms in psychiatric patients, as reported by Myrna M. Weissman, PhD (242:742, 1979), there may be in others. A higher occurrence of anxiety and mood depression around the time of menopause has been noted in gynecologic patients.¹ Furthermore, suicide as well as mental illness in general show peak incidences during the menopausal years.^2,3 Depressive symptoms such as insomnia, irritability, and somatic preoccupations may in some cases be related to estrogen lack, because they are alleviated by estrogen replacement.⁴ Certain changes in menopausal women of some brain enzymes or neurotransmitters subserving mood may be risk factors for depression,⁵ and, therefore, clinical and research interest in the possible association between menopause and depression ought to be maintained. . . . [Full Text PDF of this Article]

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