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Occurrence With Portal Hypertension, Hypoalbuminemia, and Hypersplenism

William G. B. Graham, MD; G. Richard Dundas, MD

JAMA. 1979;242(4):353-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ISONIAZID is reported to cause mild usually asymptomatic hepatocellular dysfunction manifested by elevations of the serum transaminase levels in 10% to 20% of patients.¹ Clinically apparent hepatitis occurs in 1% to 2% of patients, occasionally resulting in fatal hepatic necrosis.¹ The majority of deaths reported have occurred in blacks. The clinical syndrome of cirrhosis with ascites, peripheral edema, portal hypertension, eosphageal varices, and hypoalbuminemia associated with isoniazid has not been described, although histological evidence of cirrhosis has been present in some autopsy or biopsy specimens.^2-4 We report severe isoniazid-related chronic hepatic damage with clinical cirrhosis occurring in a white woman, whose condition improved after discontinuation of the treatment.

Report of a Case

A 57-year-old white woman was given prophylactic isoniazid, 300 mg/day, because of apical scarring on chest roentgenogram and a positive tuberculin skin test.

After eight months of taking the medition and not showing symptoms, she noted . . . [Full Text PDF of this Article]

Author Affiliations
From the Pulmonary Unit, Department of Medicine, University of Vermont College of Medicine, Burlington (Dr Graham), and the Putnam Memorial Hospital, Bennington, Vt (Dr Dundas).

Footnotes
Reprint requests to Pulmonary Unit, Medical Center Hospital, Burlington, VT 05401 (Dr Graham).

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