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Julian Lieb, MD
Yale University School of Medicine New Haven, Conn

JAMA. 1980;243(1):32.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Prostaglandin synthesis inhibitors such as ibuprofen, aspirin, and indomethacin can be effective in the prophylaxis of acute gastrointestinal symptoms following the ingestion of certain foods, ie, pork chops, mussels, sweet corn, eggs, bananas, shellfish, wine, beer, citrus fruit,¹ and dairy products.^1,2

Report of a Case.—

A 32-year-old woman had a ten-year history of intolerance to coffee. Even small quantities of black coffee were capable of inducing abdominal cramps and diarrhea. She readily agreed to a coffee challenge following aspirin prophylaxis.

On three successive mornings, she took 975 mg of aspirin followed, one half hour later, by two large mugs of sugarless, black coffee and was not troubled by her customary gastrointestinal symptoms.

Comment.—

This finding suggests that coffee may cause an excessive release of prostaglandins, possibly by stimulating prostaglandin synthetase. The physiological effects of coffee, including insomnia, might therefore be mediated through an excessive release . . . [Full Text PDF of this Article]

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